Boer, P. de (2011) The activation of the NLRP3 and NLRP1 inflammasomes provide a new insight in the progression of Alzhemeimer's disease. Bachelor's Thesis, Biology.
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Abstract
Inflammasomes are intracellular multimeric protein complexes, consisting of an NLR-domain, a caspase recruitment domain and pro-caspase-1. Inflammasomes play a role in the innate immune-system by sensing pathogen associated molecular patterns (PAMPs) and danger associated molecular patterns (DAMPs). This leads to caspase-1 acitivity, which subsequently cleaves pro-IL-1β and pro-IL-18 to the active pro-inflammatory cytokines IL-1β and IL-18. Inflammasomes might be involved in the induction of inflammation associated with progression of Alzheimer’s disease (AD). It seems that the NLRP3 inflammasome is activated in microglia by amyloid-β (Aβ) trough lysosomal damage and that the NLRP1 inflammasome is also activated by Aβ in neurons as a result of K+ efflux. This leads to neuro-inflammation and neuronal cell-death, thereby enhancing the AD pathology. These findings might lead to therapeutic implications aiming for the inhibition of inflammasome activity in AD. And possibly other neurodegenerative diseases associated with inflammation.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 15 Feb 2018 07:45 |
| Last Modified: | 15 Feb 2018 07:45 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/9563 |
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