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cAMP signalling: the role of PKA, Epac and AKAPs in Alzheimer’s disease.

Kuiper, E.F.E. (2011) cAMP signalling: the role of PKA, Epac and AKAPs in Alzheimer’s disease. Bachelor's Thesis, Biology.

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With increasing age, diseases related to age like Alzheimer’s Disease (AD), occur more frequent. AD is a multifactorial disease, characteristics are degeneration of neurons and synapses, deposits of Amyloid β (Aβ) and intracellular tangles of hyperphosphorylated tau. Disruption of neurotransmitter systems is a consequence of this. G protein-coupled receptors (GPCRs) and the signalling pathway of cAMP play an important role in these systems. To regulate the cAMP signalling pathway there are effector proteins of cAMP, like protein kinase A (PKA) and exchange proteins activated by cAMP (Epacs) connected to anchoring proteins like A kinase anchoring proteins (AKAPs). AKAPs are found throughout the body and can regulate numerous processes. They also play a role in neuronal cells, including neurons involved in learning and memory consolidation and retrieval. In neuronal cells AKAPs can regulate cAMP signalling and glutamatergic signalling. In Alzheimer's disease these signalling pathways are disturbed and looking at AKAPs in Alzheimer's could provide an integrated view of involved processes.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:45
Last Modified: 15 Feb 2018 07:45

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