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Nutlin-3 as targeting drug

Boer, B. de (2011) Nutlin-3 as targeting drug. Bachelor's Thesis, Biology.

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The interaction of the tumorsupressor protein p53 with MDM2 is a potential target for small inhibitors like Nutlin-3, RITA and Ml-219. MDM2 is the major negative regulator of p53 through a negative feedback loop. Inhibiting the MDM2-complex with for example Nutlin-3 leads to a higher expression of the p53 protein. The effects of Nutlin-3 are mostly seen in tumor cell lines with wild-type p53 whereas cell lines with mutated p53 often show less or less effect. In cell lines with mutated p53 other pathways need to be activated. Cell cycle arrest seems to be the main response of wild-type p53 cells to Nutlin-3 treatment but the exact mechanism is still unclear. This study further gives an overview of different cancers and the effect of Nutlin-3 treatment on these cancers including some other drugs interfering in the p53-MDM2 interaction. Overall Nutlin-3 is a promising drug which has a future in front of it.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:46
Last Modified: 15 Feb 2018 07:46

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