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The Differentiation Choice of Bone Marrow-derived Cells

Stijl, R. van der (2011) The Differentiation Choice of Bone Marrow-derived Cells. Bachelor's Thesis, Biology.

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ABSTRACT. Bone marrow derived cells (BMDC) have shown to engraft renal tubuli and constitute part of the interstitial myofibroblast population after kidney damage. It is unknown which BMDC are responsible for the differentiation towards tubular epithelial cells (TEC) or myofibroblasts. Mesenchymal stem cells, haematopoietic stem cells, fibrocytes, peripheral blood mononuclear cells, fibroblasts and pericytes are all resident or peripheral BMDC. They each show in vitro or in vivo differentiation capability towards either TEC or myofibroblasts, creating a complicated web of cells that can contribute to renal recovery. With the help of literature research the signalling molecules that affect this differentiation are identified. In the damaged kidney, inflammation and wound healing create a specific microenvironment. The composition of this microenvironment will determine the differentiation choice of arriving BMDC towards TEC or myofibroblast. By studying the damaged kidney‟s gene transcription and protein levels it is possible to predict the microenvironment and hypothesize which differentiation choice the BMDC will make. At the moment of BMDC arrival the microenvironment is predominantly pro-fibrotic, therefore BMDC will mainly choose to differentiate towards myofibroblasts.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:46
Last Modified: 15 Feb 2018 07:46

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