Weide, H. van der (2011) The development of Nanodisc technology as a model membrane system in membrane protein research. Bachelor's Thesis, Biology.
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Abstract
This literature research focuses on the recent development of a new artificial system in which membrane proteins can be reconstituted: Nanodiscs. It will introduce with a general overview of the model membrane systems used for membrane protein reconstitution in biochemical research. A short review of early research into the high density lipoprotein complex is then followed by in-depth reviews of the article describing the engineering of the original membrane scaffold protein that makes up the Nanodisc and two following studies that further developed the membrane scaffold protein. Another three in-depth reviews cover the first membrane protein to be reconstituted into Nanodiscs, the demonstration of the use for Nanodiscs in single-molecule studies and the development of oligomeric Nanodisc reconstitution, followed by recent examples of the Nanodisc technology applied to membrane protein research.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 15 Feb 2018 07:46 |
| Last Modified: | 15 Feb 2018 07:46 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/9748 |
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