Neervoort, J. (2020) Plasma Biomarkers: A Possible Way to Predict Effectivity of PD-L1 Blockade Therapy. Bachelor's Thesis, Life Science and Technology.
|
Text
bLST_2020_NeervoortJ.pdf Download (544kB) | Preview |
|
![[img]](https://fse.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
toestemming.pdf Restricted to Registered users only Download (134kB) |
Abstract
Hodgkin lymphoma is one of the most frequent lymphomas in the Western world and is characterized by an extremely low number of tumor cells within a large microenvironment. Treatment of Hodgkin lymphoma by radiotherapy and chemotherapy is very effective, but is highly toxic, causing second malignancies to be the leading cause of death among Hodgkin lymphoma survivors. Partly because of the large microenvironment surrounding the tumor cells, immune checkpoint blockade therapy targeting the PD-1/PD-L1 axis has shown great efficacy in relapsed and refractory Hodgkin lymphoma patients. Selection for potential responders to immunotherapy is very important and can be realized by determination of predictive soluble biomarkers. The aim of this thesis is to identify the potential prognostic and predictive value of sPD-L1, sPD-L2, sPD-1, Indoleamine 2,3-dioxygenase (IDO), sCD83, and VEGF for PD-1 blockade therapy, and the possible impact of these soluble biomarkers on the PD-1/PL-L1 axis in Hodgkin lymphoma. We found that sPD-L1 and sPD-1 are promising independent predictive biomarkers and combination PD-1 blockade therapy with anti-IDO or anti-VEGF antibodies might provide a solution for resistance to immune checkpoint inhibition.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Berg, A. van den |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 04 May 2020 11:55 |
| Last Modified: | 04 May 2020 11:55 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/21850 |
Actions (login required)
 |
View Item |