Vries, Mervin de (2022) FXR is an essential metabolic regulator in the context of bariatric weight loss surgery. Bachelor's Thesis, Life Science and Technology.
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Abstract
To combat obesity, health professionals often use lifestyle interventions and pharmacotherapy. These treatments are often ineffectieve, especially in extreme cases. Bariatric surgery has shown incredible durable weight reduction and remission of related comorbidities. Positive effects seem not to only result from weight loss alone, and are not explained by the primary malabsorption induced by bariatric surgery. Numerous gut hormones have been investigated around these effects. However, it remains a goal to understand the hormonal and metabolic mechanisms behind bariatric surgery and if this can provide therapeutic targets. The bile acid(BA) sensing farnesoid X receptor (FXR) is of interest in this regard as it is less known than other regulators in the gastrointestinal tract but has shown to have great metabolic regulating potentials such as lipid metabolism, bile acid, and glucose homeostasis. This thesis reviews known functions of FXR with BA as its primary ligand and it's main effectors (FGF19) in the context of bariatric surgery. FXR is an essential regulator in the context of bariatric surgery and is related to many beneficial effects. Contradicting effects concerning this signaling pathway are observed, and thus FXR has a narrow therapeutic window. There are ill-researched correlations of FXR pathways, dumping syndrome/late hypoglycemic syndrome and possibly weight regain in the context of intestinal hyperplasia.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Jonker, J.W. and Struik, D. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 18 Aug 2022 11:37 |
| Last Modified: | 18 Aug 2022 11:37 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/28331 |
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