Exploring the multifaceted nature of mTOR signaling in cancer

Caldarola, Andrea (2023) Exploring the multifaceted nature of mTOR signaling in cancer. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

The mechanistic target of rapamycin (mTOR) is a protein kinase that plays an important role in regulating various cellular processes related to growth, survival, and proliferation, including protein, nucleotide, and lipid synthesis, as well as autophagy. mTOR mediates its regulatory functions as the catalytic subunit of two protein complexes: mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2). Many cancers present hyperactivation of mTORC1, which results in uncontrolled cellular growth and proliferation, and, consequently, tumor initiation and progression. The clinical use of rapalogs, the first generation of mTOR inhibitors, has so far proven challenging, owing to their limitations in effectively inhibiting mTORC1, as well as to the fundamental drawbacks associated with mTORC1 inhibition. This essay presents recent advancements within the field of mTOR signaling in cancer, with a focus on research surrounding the development of enhanced new-generations of mTOR inhibitors, improved targeting of mTOR inhibitor-sensitive cancers, effective combination strategies, as well as mTOR-activating approaches. Based on these advancements, suggestions for areas to be focused on in future research are provided.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Calkhoven, C.F.
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	08 Nov 2023 10:58
Last Modified:	08 Nov 2023 10:58
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/31617

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