Blom, Daniëlle (2024) Determining repeatability and precision of sodium concentration in calf muscle of healthy human test subjects with 23Na-MRI. Master's Thesis / Essay, Biomedical Engineering.
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Abstract
Background: Increased sodium storage has been found chronic kidney disease patients. Sodium concentration is therefore proposed to be assessed as clinical biomarker in kidney failure intervention studies. To implement this, sodium concentration needs to be quantified. The goal of this study was to inspect the feasibility and repeatability of quantifying sodium concentration in muscle and skin of healthy subjects with 23Na-MRI at 7T. Methods: 10 healthy participants were scanned on a 7T MRI using a double-tuned transmit/receive RF coil with two sodium and two proton channels. 4 ROIs were analysed: m. gastrocnemius, m. soleus, m. tibialis anterior and the skin. Quantification was done using reference phantoms with known sodium concentrations. Intersession and intrasession repeatability were assessed in 15 min 3D FFE and 5 min 3D FFE sodium scans with BlandAltman plots and the coefficient of repeatability. Accuracy was evaluated by comparison to literature. An exercise test was performed as a proof of concept to test physiological differences in a short time frame using multiple 5 min scans. Results: 15 min scan found mean sodium concentrations of 16.7±3.8 mmol/L (gastrocnemius), 15.6±4.1 mmol/L (soleus), 10.8±2.4 mmol/L (tibialis anterior) and 15.5±2.8 (skin). Coefficient of repeatability for gastrocnemius, soleus, tibialis anterior and skin in 15 min scans are respectively: 51.8%, 48.9%, 25.3% and 49.7%. 5 min scan found mean sodium concentrations of 17.3±3.0 mmol/L (gastrocnemius), 13.6±3.7 mmol/L (soleus), 7.4±2.1 mmol/L (tibialis anterior) and 15.2±2.1 mmol/L (skin). Coefficient of repeatability for gastrocnemius, soleus, tibialis anterior and skin in 5 min scans are respectively: 59.2%, 24.0%, 34.4% and 32.6%. Conclusion: Proposed quantification method showed good accuracy in the 15 min scan, but showed inadequate repeatability for determining physiological differences in renal disease patients. The 5 min scan showed both poor accuracy and repeatability. For this method to be implemented in intervention studies, improvements in repeatability and accuracy should be made.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Renken, R.J. |
| Degree programme: | Biomedical Engineering |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 13 Aug 2024 10:03 |
| Last Modified: | 14 Aug 2024 14:09 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/33875 |
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