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Which pressure-sensitive adhesives are used in medicine?’

Schouten, M. (2010) Which pressure-sensitive adhesives are used in medicine?’. Bachelor's Thesis, Biology.

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Pressure-sensitive adhesives (PSAs) are a broad department of adhesives with a lot of application possibilities. This could be in industry, but also in medicine. The main question forthis thesis is: ‘Make an overview of pressure sensitive adhesives used in medicine.’ To answer the main question, the definition of PSAs is given first. After this the applications of PSAs are explained. To know the properties of an adhesive to adhere with a surface or substrate a chapter is made to explain the important properties of PSAs. After the important properties, testing methods are explained and at last the future directions in PSAs. A general definition to define an adhesive is: ‘A material capable of bonding and holding adherents together by means of surface attachment (1).’ To distinguish PSAs from general adhesives two essential requirements are important and have always been remembered when choosing or developing a PSA (4;5): - The adhesive have to stick firmly to a difficult surface like human skin. - The adhesive should be easily and cleanly removed from the substrate when desired. It will not cause skin irritation due stripped Corneocytes. The applications for PSAs on the market are mostly for wound protection. The applications for PSAs are (3): - Drug delivery systems. - Moisture vapor permeable (MVP). - Traumaless removable. - Water resistant. - For electro-medical applications. Pressure-sensitive adhesives have to adhere to the human skin and need some properties to make an adhesive bond. These properties are (7): - Surface free energy - Polarity - Rheological properties Many testing methods are available to quantitatively characterize the interfacial strength between the substrate or surface and the PSA. Among all tests the peel and the blister tests are the most popular ones, in the industry and in the academy (12;13). In literature there are a few future directions available: - Problem in repeated removal of adhesives, with as result stripped corneocytes. This can be solved by using a water solvable PSA. The adhesive will lose its adhesiveness and can be removed easily (3). - Impregnating the adhesive with a broad spectrum antibiotic or use drug delivery systems as specific antibiotics delivery through the skin (18). - Bio-engineered tissue with stem cells (18). - Another new type of medical adhesives, for instants the hydro gels (18).

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:45
Last Modified: 15 Feb 2018 07:45

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