The influence of BMAL1 polymorphisms on the sensitivity to winter depression

Nisar, Z (2012) The influence of BMAL1 polymorphisms on the sensitivity to winter depression. Bachelor's Thesis, Biology.

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Abstract

Some people experience a serious mood change when the seasons change. Seasonal Affective Disorder (SAD) is a mood disorder. The term 'winter depression' describes a form of SAD that occurs in the winter months: people who have normal mental health throughout most of the year experience depressive symptoms in the winter year after year. One of the major theories for explaining SAD involves the circadian rhythms of the body. Brain and muscle Arnt-like protein-1 BMAL1 is a transcription factor playing a central role in the regulation of circadian rhythms. Mutations in or deletions of a single circadian clock gene cause alterations to the circadian rhythms. Polymorphisms of circadian clock genes Per2, BMAL1, and Npas2 contribute to winter depression. Several polymorphisms of BMAL1 can be selected to determine their influence on winter depression sensitivity. Single-nucleotide polymorphism rs2290035 in the BMAL1 gene may regulate the circadian activities of BMAL1. Because of these alterations in the circadian rhythms, it has a direct influence on patients mood and can influence the person's sensitivity to winter depression.

Item Type:	Thesis (Bachelor's Thesis)
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	15 Feb 2018 07:48
Last Modified:	15 Feb 2018 07:48
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/10041

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