The role of stem cell aging in acute myeloid leukemia.

Roos, M.J de (2016) The role of stem cell aging in acute myeloid leukemia. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

Throughout life, the hematopoietic system produces and replenishes blood cells. Hematopoiesis is a tightly regulated process, but alterations and mutations can give rise to tumors. Leukemia is a disease which occurs at all ages, but the incidence of Acute Myeloid Leukemia (AML) strongly increases with age. AML can be defined as a heterogeneous oligoclonal disorder with several different mutations at its origin. It remains under debate whether Hematopoietic Stem Cells (HSC) or Hematopoietic Progenitor Cells (HPC) are the cell of origin in AML. A strong increase in AML incidence is observed with an increase in age, but much remains unclear regarding the role of aging in the development of AML. In contrast to younger patients, AML in the elderly is increasingly resistant to chemotherapy resulting in a poor prognosis. Research has revealed that aging alters stem cell functions. Both extrinsic and intrinsic factors are believed to contribute to aging of the hematopoietic system. Here, we discuss recent developments regarding the role of intrinsic and extrinsic factors in stem cell aging. Moreover, we speculate how these findings can contribute to the increased incidence of AML in the elderly.

Item Type:	Thesis (Master's Thesis / Essay)
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	15 Feb 2018 08:12
Last Modified:	15 Feb 2018 08:12
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/13966

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