Research report 1: The effects of tacrolimus on potential drug targets FKBP65 and FKBP22

S.G. Fuhler (2016) Research report 1: The effects of tacrolimus on potential drug targets FKBP65 and FKBP22. Bachelor's Thesis, Biology.

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Abstract

Collagen is one of the most abundant proteins in the human body. The over-stimulation of collagen is called fibrosis. One possible group of drug targets for fibrosis are FK506-binding proteins (FKBP). FKBP65 and FKBP22 are involved in the biosynthesis of collagen as molecular chaperones and folding enzymes. Mutations of FKBP10 and FKBP14 (genes encoding FKBP 65 and FKBP22) have been shown to be a cause of several connective tissue disorders. Recently, this gained them attention as potential drug targets. FK506 (tacrolimus) is a immunosuppressive drug used in organ transplantations which interacts with FKBPs. It has been shown to have an anti-fibrotic effect in several fibrotic diseases, mainly working through inhibiting TGF-B and TGF-B activated pathways. TGF-B is a known fibrosis inducing cytokine and has been extensively researched in association with fibrosis. Research investigating the effect of tacrolimus on FKBPs in relation to fibrosis is, however, less common. In this report it was tried to establish what is known about the potential of tacrolimus as an anti- fibrotic drug effecting FKBP65 and FKBP22. Because the interest in this field only recently came up, the literature on this subject is sparse, but the cautious conclusion that mainly FKBP65 is not a good drug target for tacrolimus is drawn. This does not negate the potential of FKBP65 and FKBP22 as potential drug targets but does imply that tacrolimus might not be the drug to exploit this potential.

Item Type:	Thesis (Bachelor's Thesis)
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	15 Feb 2018 08:13
Last Modified:	15 Feb 2018 08:13
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/14134

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