The role of vitamin D in arterial stiffness: A potential target in the treatment of CKD-related cardiovascular complications

Karunenthiran. J (2016) The role of vitamin D in arterial stiffness: A potential target in the treatment of CKD-related cardiovascular complications. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

Chronic kidney disease (CKD) is a major cause of mortality worldwide, largely due to an increased risk of cardiovascular disease (CVD). Abnormalities of bone and mineral metabolism are strongly involved in the increased cardiovascular and CKD mortality. Notably, vitamin D deficiency is frequently found in CKD and CVD patients. Another important predictor of all-cause mortality in CVD and patients undergoing kidney transplantation is arterial stiffness. Moreover, many risk factors of CKD and CVD, such as diabetes and hypertension are associated with arterial stiffness. Interestingly, several studies reported a link between vitamin D deficiency and arterial stiffness. Vitamin D supplementation has shown to improve endothelial function and arterial stiffness in animal models. In contrast, some studies demonstrated increased serum vitamin D levels to be associated with increased risk of hypertension and vascular stiffening. This suggests, although several studies investigated the association between vitamin D and arterial stiffness, the exact link and underlying mechanisms remain to be unraveled. Therefore, this review aimed to evaluate the currently-available literature on the link between vitamin D and arterial stiffness. Herein, we gave an overview of the most important studies concerning vitamin D supplementation and arterial stiffness. To further demonstrate the involved pathogenesis, we focused on the role of the endothelium.

Item Type:	Thesis (Master's Thesis / Essay)
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	15 Feb 2018 08:25
Last Modified:	15 Feb 2018 08:25
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/14525

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