Can the peripheral innate immune system be involved in the onset of the development of Alzheimer’s disease?

Kamphuis, Annelies (2018) Can the peripheral innate immune system be involved in the onset of the development of Alzheimer’s disease? Master's Research Project 1, Biomedical Sciences.

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Abstract

Alzheimer's disease (AD) accounts for 60-80% of all dementia cases and is therefore the most common form. For a few decades now, the amyloid cascade hypothesis has been considered as the main concept in AD pathology research, stating that the accumulation as well as the deposition of Aβ peptides is the trigger of the onset of AD. However, recently, a new important pathological hallmark has emerged, the neuroinflammatory reaction mediated by innate immune cells. This review will answer if the peripheral innate immune system can be involved in the onset of the development of AD. The innate immune response in the central nervous system, the innate immune response in the periphery, the interaction between peripheral immune cells and microglia, and peripheral infections in AD will be discussed. The activation of peripheral innate immune cells most likely functions as an early biomarker of the onset of the development of AD. A large amount of data discussed is consistent with the involvement of the peripheral innate immune system, particularly in the early-stage of AD. Although, to further support the role of the peripheral innate immune system as a trigger, more thorough research is required. If the aforementioned hypothesis is correct, supporters of the amyloid cascade hypothesis will have to modify their theories about the AD pathology. Eventually, this may lead to the revelation of new therapeutic targets regarding the prevention and treatment of this still untreatable disease.

Item Type:	Thesis (Master's Research Project 1)
Supervisor name:	Eisel, U.L.M.
Degree programme:	Biomedical Sciences
Thesis type:	Master's Research Project 1
Language:	English
Date Deposited:	28 Mar 2018
Last Modified:	04 Apr 2018 09:15
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/16626

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