Kraeima, Bram (2018) Measuring heat distribution in bone during radiofrequency ablation. Master's Internship Report, Biomedical Engineering.
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Abstract
Radiofrequency ablation (RFA) is an increasingly desirable method for treating small tumors in bone, however adapting RFA treatment to the variations in bone tumor size is still challenging. Models on heat distribution during RF ablation in bone are rarely available. Therefore this research focused on defining the important parameters and methods involving temperature measurements and gaining insight in heat distribution in bone through performing a RF ablation experiment on pork femurs while recording temperature data at ascending distances from the ablation electrode. The temperature data shows variation between the used samples and deviations from the expected values. Variation is assumed to be caused by inaccurate sensor placement, variation in diameter of drilled holes required for sensor placement and uncontrolled ambient temperatures during the ablation. Furthermore a limited amount of temperature sensors reduced the temperature resolution from ideal. An ideal method for measuring and visualizing the heat distribution in bone during RF ablation includes MRI thermometry, based on ultra-short echotime sequences, to visualize the heat distribution in 3D and validate through using an fiber optic FBG sensor. MRI thermometry also enables online feedback, however continuous RFA and MRI thermometry requires MRI compatible RFA needles and a low pass filter between the RFA generator and electrode.
| Item Type: | Thesis (Master's Internship Report) |
|---|---|
| Supervisor name: | Verkerke, G.J. |
| Degree programme: | Biomedical Engineering |
| Thesis type: | Master's Internship Report |
| Language: | English |
| Date Deposited: | 03 May 2018 |
| Last Modified: | 11 May 2018 14:41 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/16824 |
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