Precision-cut kidney slices as a model for acute kidney injury

Russel, Stefan Alfred Hendrik (2018) Precision-cut kidney slices as a model for acute kidney injury. Research Project, Pharmacy.

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Abstract

Acute kidney injury (AKI) is worldwide a major health concern and the incidence has increased over time. There is, as of now, no medical intervention that significantly impacts AKI. A factor that can cause AKI is ischemia/reperfusion injury (IRI), which is restriction of blood to the kidney followed by restored blood flow. Mitochondrial dysfunction plays a critical role in the progression of renal IRI. Here, we looked at murine precision-cut kidney slices (PCKS) as a model for renal IRI. Furthermore, a compound that theoretically improves mitochondrial functionality, SUL-138, was added during incubation to possibly combat kidney IRI

Item Type:	Thesis (Research Project)
Supervisor name:	Graaf, I.A.M. de
Degree programme:	Pharmacy
Thesis type:	Research Project
Date Deposited:	03 Sep 2018
Last Modified:	12 Jul 2019 12:11
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/18500

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