Jansma, Jack (2018) Understanding causality and treatment of bacterial dysbiosis in the human gut using systems biology approaches. Master's Thesis / Essay, Molecular Biology and Biotechnology (2016-2019).
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Abstract
Bacteria are living in symbiosis in the human gut. Here bacteria can have positive effects on the host immune system, central nervous system and digestive tract. A dysbiosis in the human gut may result in serious diseases, such as inflammatory bowel disease and major depressive disorder. However the onset of the disease and the mechanism of action of possible treatments is not well understood. Systems biology can discover emergent properties of a network via mathematical modeling, thus systems biology can help unraveling both problems. Systems biology approaches can be divided into top-down and bottom-up approaches. The top-down approach uses –omics approaches to construct a network based on quantitative, experimental data. Keystone species can be identified with this approach, which leads to a better understanding of the microbiota structure. The bottom-up approach uses mathematical models to look for novel interactions in a network. The bottom-up approach mainly uses different types of flux balance analysis. Via the addition of a probiotic or prebiotic to a model the mechanism of action can be determined. This study gives an overview of different systems biology approaches in microbial research and shows the possibilities of these approaches.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Milias Argeitis, A. |
| Degree programme: | Molecular Biology and Biotechnology (2016-2019) |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 26 Nov 2018 |
| Last Modified: | 03 Dec 2018 13:21 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/18846 |
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