Piebenga, Dillon (2020) Damage Associated Molecular Patterns from the extracellular matrix in Chronic Obstructive Pulmonary Disease. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a lung disease characterized by obstruction of the airways as a result of chronic inflammation often caused by noxious particles or gasses such as cigarette smoke. This chronic inflammatory milieu leads to a cascade of changes within lung tissue, such as extra cellular matrix (ECM) remodeling. Damage associated molecular patterns (DAMPs) have been of particular interest for the pathogenesis and pathology of COPD and have been found to play a significant role in inflammatory processes induced by noxious stimuli in epithelial cells. DAMPs released from necrotic epithelial cells lead to immune activation and leukocyte infiltration, especially innate immune cells such as neutrophils and macrophages, in lung parenchyma. In this review we focus on ECM proteins that act as DAMPs when released from the degraded ECM and how they are involved in the pathophysiology of COPD.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Burgess, J.K. and Pouwels, S.D. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 17 Feb 2020 10:09 |
| Last Modified: | 17 Feb 2020 10:09 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/21567 |
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