The Pathogenesis of SARS-CoV-2

veenma, vivianne (2020) The Pathogenesis of SARS-CoV-2. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

Being the third big outbreak of a coronavirus in the past two decades, SARS-CoV-2 has spread over the world and is claiming thousands of lives. To prevent more casualties and work towards a vaccine it is important to understand the pathogenesis and life cycle of the virus. The virus can spread in two ways; through respiratory droplets and the fecal-oral route. Both transmission routes result in the virus entering the lungs and attacking the alveoli cells. The virus attaches it’s S spike to the ACE2 receptor of the host cell and enters either by way of an endosome or through direct membrane fusion. It then hijacks the host and replicates causing damage to the host cell, which results in the production of pro-inflammatory cytokines that attract immune cells. From here the patient can either experience a mild infection in which the patient will have symptoms like a fever, cough and difficult breathing, or a severe infection when the huge amount of cytokines produced (cytokine storm) migrate through the blood and cause Multi System Organ Failure (MSOF), which can be fatal. In the mild infection the cytokine storm is prevented by T cells and macrophages that clear the infection. Even though this review gives critical insight into the pathogenesis of SARS-CoV-2 there are remain a lot of gaps that need to be cleared by future research.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Huckriede, A.L.W.
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	08 Jun 2020 14:06
Last Modified:	08 Jun 2020 14:06
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/22020

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