Günal, Dilay (D.J.A) (2020) A protective mechanism proposed against beta-amyloid plaques in the cerebellar environment. Bachelor's Thesis, Life Science and Technology.
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Abstract
The cerebellum has long been considered as only being essential for the coordination of movements. However, the idea that the cerebellum is involved in cognition and emotion, has shed light on a whole new branch within neuroscience research. Nevertheless, the cerebellum is still often neglected in research in cognitive decline. The current ever-ageing population is accompanied by an increase of people suffering from neurodegenerative diseases. Therefore, this thesis reviews the ageing process in the cerebellum, as well as the unique cerebellar pattern in Alzheimer’s Disease (AD). This analysis puts emphasis on the cerebellar environment and the link between normal healthy ageing and pathological ageing in AD. The characteristic beta-amyloid (Aβ) aggregations and neurofibrillary tangles (NFT) are both less present or even absent in the cerebellum. As the cerebellum is the last brain region to accumulate these markers, it appears that the it provides amongst others greater microglial clearance of Aβ-aggregations in contrast to the rest of the brain. Moreover, it is indicated that cerebellar neurons might provide a protection against AD-pathology. In conclusion, the cerebellar environment might have certain built-in mechanisms to protect against the aggregation of Aβ and is therefore considered as an important key player in cognitive decline. In order to have a better understanding of AD and find a possible cure, the cerebellum should be taken into account for future research.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Zee, E.A. van der |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 10 Jul 2020 11:21 |
| Last Modified: | 10 Jul 2020 11:21 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/22531 |
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