Alzheimer’s Disease and Sleep Disturbance: Neuroinflammation, Glymphatic Clearance and the Noradrenergic Mechanism

Wouda, H. T. (Sterre) (2020) Alzheimer’s Disease and Sleep Disturbance: Neuroinflammation, Glymphatic Clearance and the Noradrenergic Mechanism. Bachelor's Thesis, Biology.

Preview	Text Bachelor Thesis H. T. Wouda.pdf Download (497kB) | Preview
	Text toestemming.pdf Restricted to Registered users only Download (134kB)

Abstract

Ageing is an important factor for the development of sleep disorders and neurodegenerative disorders, such as Alzheimer’s disease (AD). One characteristic of AD is increased sleep disturbances. In addition, sleep loss or disturbances are associated with different conditions or mechanisms affecting or causing AD. In this review, three different aspects associated with AD and affected by sleep loss are covered. This includes neuroinflammation, the glymphatic clearance pathway and the role of the locus coeruleus (LC) and its neurotransmitter noradrenaline (NA). Neuroinflammation is known as a characteristic of AD, resulting in neuronal cell loss and the accumulation of amyloid-beta (Aβ). The glymphatic clearance mechanism is a system in the brain regulating the clearance of waste products and possible toxic metabolites, including Aβ. Hence, when this system is disturbed it can contribute to AD pathology. The LC-NA mechanism is known for its mediating function in arousal and stress. Next to that, NA has possible neuroprotective and anti-inflammatory effects. When this system is disturbed it can contribute to AD pathology. All these three conditions/mechanisms are affected or mediated by sleep. Sleep loss is associated with increased neuroinflammation, dysfunctioning of the glymphatic clearance and dysfunctioning of the LC-NA system. Therefore, sleep loss contributes directly and indirectly to AD pathology. I suggest a feedback circle of sleep disturbance, neuroinflammation, glymp

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Eisel, U.L.M.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	17 Jul 2020 09:20
Last Modified:	17 Jul 2020 09:20
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/22744

Actions (login required)

View Item