Rolwes, Joeri (2020) Human herpusvirus 6: a risk factor for multiple sclerosis. Bachelor's Thesis, Biology.
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Abstract
Multiple sclerosis (MS) is a complex disease consistent of various phenotypes of which the exact origin is unknown. It is considered a combination of an inflammatory mediated auto immune disease with a neurodegenerative disease. Known risk factors for the development of MS are genetic predispositions and environmental factors such as smoking. More recently it is believed that viral infections such as human herpesvirus 6 (HHV6) can be an environmental risk factor for MS as well. Through the mechanism of molecular mimicry, HHV6 is considered to activate the autoimmune response that marks the pathogenesis of MS. Moreover, various studies suggest that HHV6 influences the concentration of TNF-α, a pro-inflammatory cytokine, which plays an important role in the development and progression of the disease. Other viruses such as the Epstein-bar virus (EBV) have been studied more extensively and have more proof substantiating the idea that viruses might contribute to the disease development. Although there have been many studies that presented evidence substantiating the idea that HHV6 is a risk factor for MS, the vast majority of that evidence is very circumstantial. It is because of this that many believe there to be no role for HHV6 and conducted meta-analysis in combination with alternative theories have tried to disprove the role of HHV6 in MS. Nevertheless, the admittingly circumstantial evidence does indicate a possible role for HHV6 in MS.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Eisel, U.L.M. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 22 Jul 2020 10:02 |
| Last Modified: | 22 Jul 2020 10:02 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/22835 |
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