Boelen, Thijs (2021) Brain Collagen in Post Operative Cognitive Dysfunction. Bachelor's Thesis, Life Science and Technology.
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Abstract
Post Operative Cognitive Decline (POCD) is a relative common complication in elderly patients that underwent surgery. POCD is becoming more prevalent due to the increased number of surgeries performed in the elderly population. However, the exact mechanism of POCD development remains unknown. Currently, the prevailing theory is that neuro-inflammation plays a major role in POCD development. Interfering with neuro-inflammatory processes may provide a rational way for treatment. Accordingly, here are two potential approaches: decreasing neuro-inflammation or protecting the neurons. Most research on novel POCD treatment has been focussed on decreasing neuro-inflammation. However, none of these have as yet reached clinical practice. There is evidence that lowering neuro-inflammation may not be enough to counteract POCD development. Hence, this thesis will focus on the alternative; an approach to enhance neuro-protection. An endogenous neuroprotective system is brain collagen. Hence, we will explore whether brain collagen could provide a target for POCD treatment. Two potential ways of increasing brain collagen, oral collagen supplements and whole body vibration, are discussed. Based on previous research, a pilot study by R.G. Schoemaker et al at the University of Groningen (2021) and a combination of pharmacokinetics and the physiology of the brain, whole body vibration seemed a promising way to increase brain collagen to be studied as candidate for a novel POCD treatment.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Schoemaker, R.G. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 06 May 2021 08:55 |
| Last Modified: | 06 May 2021 08:55 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/24356 |
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