Michorius, Lize (2021) The foreign body response to biodegradable polymers orchestrated by macrophages and the influence of anti-inflammatory drugs on this process. Bachelor's Thesis, Life Science and Technology.
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Abstract
At various stages of the foreign body reaction, macrophages control the proliferative response by secreting chemokines, cytokines and growth factors. Despite the fact that macrophages are thought to be primarily engaged in unwanted breakdown and biomaterial rejection, it is now known that they are required for correct integration of non-degradable biomaterials and destruction of degradable biomaterials such as biodegradable polymers. The aim of this thesis was to give insight into the foreign body response orchestrated by macrophages to the implantation of biodegradable polymers and how anti-inflammatory drugs can affect macrophages in this process. Anti-inflammatory drugs were found to have an inhibiting effect on prostaglandin synthesis and therefore on inflammatory cytokine production. Administration of anti-inflammatory drugs could help in the shift of M1 macrophage to M2 macrophage dominance by suppressing the inflammatory cytokines so that M2 associated cytokines can take over, which is preferred in biodegradable polymer applications.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Kooten, T.G. van and Sjollema, J. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 02 Jul 2021 12:30 |
| Last Modified: | 02 Jul 2021 12:31 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/24858 |
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