Review: Stiffening of the extracellular matrix in cancer

Graaf, Myrthe de (2021) Review: Stiffening of the extracellular matrix in cancer. Bachelor's Thesis, Biology.

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Abstract

A stiffened ECM affects critical biological processes by enhancing cancer development, for example increases in proliferation and mobility of cancer cells, induction of abnormal angiogenesis, drug resistance and immunosuppression. Identifying the mechanisms that contribute to ECM stiffening is therefore of great importance to develop novel therapeutic strategies for preventing further malignant transformation. In this review, the ECM components contributing to ECM stiffening are discussed, even as the mechanisms behind ECM stiffening, the biological effects of ECM stiffening and therapeutic strategies.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Kruyt, F.A.E.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	20 Jul 2021 13:28
Last Modified:	20 Jul 2021 13:28
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/25368

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