Biomaterials: The Holy Grail for Stem Cell Therapy in the Infarcted heart

Walinga, Fokke (2021) Biomaterials: The Holy Grail for Stem Cell Therapy in the Infarcted heart. Bachelor's Thesis, Biology.

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Abstract

The ongoing high burden on society of cardiovascular diseases takes a total of 17.9 million lives per year globally in which a major one-third of these deaths are accounted by coronary artery diseases. This type of disease eventually leads to the occlusion of the coronary arteries of the heart, which consequently results in myocardial infarction. Following an infarction, ischemia-mediated cell death of the heart tissue results in the chronic failure of the heart due to contractile impairment mainly caused by fibrous scar formation. This type of injury is chronic damage to the heart that is not easily reversed. One current treatment is the use of mesenchymal stem cells, which sound promising in terms of their paracrine, differentiative, and immunomodulatory therapeutic potential along with other advantages such as its immune privilege and easy accessibility. However, the treatment with mesenchymal stem cells in the heart comes short in regard to their retention and survival due to the hostile ischemic microenvironment of the infarcted heart. Here, the use of biomaterials comes in handy to boost mesenchymal stem cell therapy. Biomaterials possess a wide variety of modifiable features and advantages in the context of cardiac tissue engineering. As for the enhancement of cell therapy, the biomaterial plays an important role by providing sufficient cell interactions along with creating a friendly microenvironment. This significantly promotes cell retention and survival. Thus ...

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Harmsen, M.C.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	29 Jul 2021 06:59
Last Modified:	29 Jul 2021 06:59
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/25495

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