Osteoarthritis: Utilization of Chondrons in Articular Cartilage Repair

Biesma, L.A. (2021) Osteoarthritis: Utilization of Chondrons in Articular Cartilage Repair. Bachelor's Thesis, Life Science and Technology.

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Abstract

Chondrocytes are cells that are responsible for the production and maintenance of articular cartilage. Chondron denominates the chondrocyte and its surrounding pericellular matrix (PCM), which has a molecular composition and unique physical properties supporting the chondrocyte. Risk factors such as age and obesity may predispose articular cartilage to damage, which is usually associated with osteoarthritis (OA). Despite the burden of over 500 million OA patients worldwide, treatment options are unsatisfactory. Autologous chondrocyte implantation (ACI) use autologous chondrocyte isolates for in vitro monolayer expansion and re-implantation to repair articular cartilage. In this strategy, the PCM is enzymatically removed, at the expense of cartilage quality. However, evidence informs us to preserve the chondron to improve cell-induced cartilage formation. Some studies have therefore focused on the co-implantation of chondrons with cells such as mesenchymal and adipose-derived stem cells and chondrocytes to treat articular cartilage lesions in in vivo models. Currently, a clinical trial (IMPACT) is running in which the role of chondrons is studied, thereby providing a refined alternative for ACI. This literature study reviews the attempts for and advances in the usage of chondrons for articular cartilage repair in the past decade. A comprehensive overview is given of the scientific developments and clinical applications with a concluding value judgment and future prospective.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Bank, R.A. and Krenning, G.
Degree programme:	Life Science and Technology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	29 Jul 2021 12:00
Last Modified:	29 Jul 2021 12:00
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/25501

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