Faecal Transplantation As a Treatment For Gut Microbiome Dysbiosis in Diabetes Type 2

Drenth, Natasja (2021) Faecal Transplantation As a Treatment For Gut Microbiome Dysbiosis in Diabetes Type 2. Bachelor's Thesis, Biology.

Preview	Text Faecal Transplantation As a Treatment For Gut Microbiome Dysbiosis in Diabetes Type 2 by Natasja Drenth (S3604853).pdf Download (589kB) | Preview
	Text toestemming.pdf Restricted to Registered users only Download (117kB)

Abstract

Out of three types of diabetes, type 2 (T2D) is the most common and characterized by insulin resistance and an impairment in secretion of insulin. Insulin regulates blood glucose levels through upregulation of glucose transporter GLUT4 in target cells. An impairment in secretion and resistance to this hormone are attributed to dysbiosis of the gut. Diets high in fats, sugars and products with a high glycaemic load and low intake of fibres have shown to cause this gut dysbiosis through reduced microbiota diversity, less short-chain fatty acid (SCFA) production and subsequently reduced production of glucagon-like peptide-1 (GLP-1) that is involved in sensitization of insulin vesicles. A reduction in GLP-1 results in decreased insulin sensitivity and reduced SCFA levels are associated with increased inflammation through pro-inflammatory cytokines and reduced production of anti-inflammatory cells. A new proposed treatment is faecal microbiota transplantation (FMT), which has shown great results in treating gut gut dysbiosis in Clostridium difficile infection. Therefore, this thesis investigates the exact role of gut dysbiosis in T2D and how FMT can aid in treatment of said dysbiosis and thus insulin resistance in T2D. FMT has shown to increase microbiota diversity, SCFA production and decrease gut inflammation. However, it is proposed that more research needs to be focussed on how to keep this state stable after FMT treatment.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Scheurink, A.J.W.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	17 Aug 2021 08:45
Last Modified:	17 Aug 2021 08:45
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/25718

Actions (login required)

View Item