The dual role of Tumour Necrosis Factor in Alzheimer’s disease

Mazenier, Bart-jan (2021) The dual role of Tumour Necrosis Factor in Alzheimer’s disease. Bachelor's Thesis, Biology.

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Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder currently affecting approximately 50 million people, with an extraordinarily large burden of disease on society, Research has been primarily focused on amyloid-beta, one of the hallmarks of AD, but has so far failed to yield treatment options that have passed clinical trials. With the advent of more modern assays, other aspects of AD, such as formation of Tau neurofibrillary tangles and the involvement of neuroinflammation can be more thoroughly investigated, opening up potential avenues for treatment. In particular, tumour necrosis factor, a master cytokine, has been shown to be correlated to earlier onset and faster progression of AD. In this review, multiple mechanisms and pathways relating to TNF, the therapeutical targets they present, and current treatments are discussed. While research into these subjects have not yet yielded a cure, there is evidence that the onset and progression of AD can be slowed, provided it is detected at an early enough stage.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Eisel, U.L.M.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	10 Sep 2021 11:59
Last Modified:	10 Sep 2021 11:59
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/26082

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