Zantinge, Danique (2022) The role of BDNF in the development of schizophrenia. Bachelor's Thesis, Biology.
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Abstract
Schizophrenia is a mental and psychotic disorder characterized by hallucinations, hearing voices, and a lack in social functioning. The disease occurs mostly as a relapsing condition and often leads to neurocognitive decline. No clear cause has been found for schizophrenia, though it is known that the disease is multifactorial. The combination of these factors leads to abnormalities in dopamine regulation and reduced crosstalk with other factors such as brain derived neurotrophic factor (BDNF). Being a neurotrophin, BDNF is responsible for many processes in the healthy brain, such as neurogenesis and facilitating synaptic plasticity. A decrease in BDNF is often found in patients with schizophrenia, raising the question whether BDNF is involved in the development of schizophrenia. Therefore, in this review, a detailed overview is provided of the functions of BDNF in healthy tissue. Further, the dysregulation of BDNF in schizophrenia is evaluated and the effect of this dysregulation on neuronal tissue is assessed. Finally, the mechanism of action and effects of some antipsychotic drugs on BDNF signaling are explained and other possible treatment options are examined.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Havekes, R. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 01 Feb 2022 10:56 |
| Last Modified: | 01 Feb 2022 10:56 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/26529 |
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