Concomitant use of oxycodone and itraconazole among long oxycodone users in community pharmacies in the Netherlands, an IADB drug-utilization study

Koszarska, Karina (2022) Concomitant use of oxycodone and itraconazole among long oxycodone users in community pharmacies in the Netherlands, an IADB drug-utilization study. Bachelor's Project, Pharmacy.

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Abstract

BACKGROUND The aim of this study was to look at the concomitant use of oxycodone and itraconazole. Oxycodone is metabolized mainly by the CYP3A4 enzyme. One of the drugs that interacts with the metabolism of oxycodone by blocking the CYP3A4 enzyme is itraconazole. Itraconazole increases the plasma levels of oxycodone and leads to stronger experience of the side effects. Therefore oxycodone and itraconazole are not preferred to be used simultaneously. METHOD For this study the IADB database was used. Oxycodone users with more than one oxycodone prescription with a period of use of at least 14 days were included. The primary outcome of this study was the incidence of concomitant use per 1000 oxycodone users. The secondary outcome was to look at the dose adjustment of oxycodone after the start of concomitant use. The exploratory part of this study investigated the difference in incidence between sexes. RESULTS In total 111 cases of concomitant use were found. The total incidence of concomitant use decreased over time from 2.75/1000 oxycodone users in 2003 to 1.16/1000 oxycodone users in 2020. There was no significant difference of concomitant use between men and women. For the dose adjustment of oxycodone the mean natural logarithm ratio of the after/before dosage was 1.58E-01 (95% CI -0.005224 to 0.3212498), meaning that there was no significant change in dosage. CONCLUSION Concomitant use of oxycodone and itraconazole does not seem to be an overlooked problem in practise.

Item Type:	Thesis (Bachelor's Project)
Supervisor name:	Bijlsma, M.J.
Degree programme:	Pharmacy
Thesis type:	Bachelor's Project
Language:	English
Date Deposited:	27 Jun 2022 12:14
Last Modified:	27 Jun 2022 12:14
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/27394

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