Clinical trials for NASH treatment: dual agonist drugs as potential treatment methods

Cate, Wouter ten (2022) Clinical trials for NASH treatment: dual agonist drugs as potential treatment methods. Bachelor's Thesis, Biology.

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Abstract

Non-alcoholic steatohepatitis is a liver disease with no approved treatment methods. Because of the severity of this disease, it is of uttermost importance to develop drugs that tackle this disease. The severity of NASH is let by permanent scarring of the liver, with hepatocellular carcinoma and liver failure as a consequence. Today, NASH screening is very difficult and mostly occurs at a later stage of the disease. Current research is focussing on various types of targets to treat this disease. Potential targets focus either on a single target, a double target or a triple target. Fibroblast growth factors are described as key players to prevent the development of NASH because they have a key role in metabolic processes that are heavily disturbed in NASH patients. Analogues of FGF19 and FGF21 have been developed for the current clinical trials which are being performed on human patients diagnosed with NASH. These FGFs have been extensively studied in mice and humans and can be used for drug development. Multiple single agonist drugs have been described, resulting in body weight reduction, impairment of liver fibrosis and a decrease in overall liver fat. Besides single agonist drugs, current clinical trials focus more on treatments with dual or triple agonist drugs. However, they have mostly been tested on mouse models, but they could make a promising option for treatment in human patients with NASH because they target more than a single pathway. In that manner,...

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Jonker, J.W. and Struik, D.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	27 Jul 2022 14:33
Last Modified:	27 Jul 2022 14:33
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/28179

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