Wijnhorst, Flo (2022) The changing microglial immune response: Cause or consequence of Alzheimer's Disease? Bachelor's Thesis, Biology.
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Abstract
Alzheimer’s Disease (AD) is a debilitating, neurodegenerative disease currently affecting more than 55 million people. The pathology is characterized by neuronal cell loss, Amyloidβ (Aβ) plaque formation, and hyperphosphorylated tau aggregates. Neuroinflammation and specifically microglia are thought to play a critical role in the onset and development of AD. Microglia represent the innate immune cells of the brain that regulate neuroinflammation through the secretion of cytokines and chemokines. Age is the most important risk factor for AD. Microglia show signs of senescence and as microglia are tightly involved in AD, it is possible that the aging of microglia affects the onset and progress of AD. This review will analyze how the phenotype of microglia changes during aging, the role of microglia in AD, and whether the changing phenotype is a cause or consequence of AD. Microglia are most likely subjected to the direct effects of aging and microglia are closely involved in the most important hallmarks of AD. Despite the difficulty of appointing a primary cause of AD, it is very well possible that aging microglia are critical in the onset of AD, and microglial aging could be a cause of the development of AD. Targeting the aging of microglia presents a promising therapeutic strategy in developing a treatment for this – as of yet – untreatable disease.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Eisel, U.L.M. and Jorna, L.M. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 09 Aug 2022 06:29 |
| Last Modified: | 09 Aug 2022 06:29 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/28291 |
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