Gkolfi, Dimitra (2022) Indirect toxic effects of nanoparticles in in vitro models of the human placenta. Master's Thesis / Essay, Medical Pharmaceutical Sciences.
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Abstract
Humans may be incidentally exposed to nanoparticles, which raises concerns about their potential toxic effects, particularly in pregnant women and developing foetuses. Advanced in vitro placental models should complement in vivo animal studies to gain insights into placenta-mediated toxicity. Using such approaches, it has been shown that CoCr nanoparticles can induce DNA-damaging signaling across BeWo cellular barriers, an in vitro model of the human placenta, and cause neuronal toxicity without crossing the barriers. These indirect effects of nanoparticles might be significant in human pregnancy since it is in early pregnancy that the placental villi are bilayered and the embryo is most vulnerable. Exposure of the human placenta to nanoparticles may have detrimental effects on the embryo during neurodevelopment. New advanced in vitro placental models with high predictive value are necessary to understand the indirect developmental toxicity of nanoparticles.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Aberg, P.H.C. |
| Degree programme: | Medical Pharmaceutical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 10 Oct 2022 08:55 |
| Last Modified: | 10 Oct 2022 08:55 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/28822 |
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