Michorius, Lize (2023) Differently structured polystyrene-b-poly(methacrylic acid) polymeric micelles and their possible use as a pH sensitive drug delivery system. Scientific Research Project, Science Education and Communication.
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Abstract
There is a problem with standard drug administration. Drugs enter healthy organs that should not be involved in a treatment and cause toxic effects. Polymeric micelles (PMs) show promising results for drug delivery applications due to their separated core/shell structure and ability to respond to external or internal stimuli when they are in vivo. In this study, different types of polystyrene-b-poly(methacrylic acid) (PSPMAA) pH sensitive polymers were used to prepare micelles and the possibility to use the PMs as a pH sensitive drug delivery system. Size, surface charge and encapsulation efficiency of all micelles were determined. All micelles show good mean encapsulation efficiencies with values between 78.16% and 85.12%, mean sizes between 96.55 and 319.00 nm and mean zeta potential between -30.55 mV and -38.15 mV. To test a possible controlled release mechanism, all of the micelles were put in solutions of pH ~7 and pH ~4 for 24 hours. Size and zeta potential was measured at the start and at the end of the release experiment for all PMs. Results show that all of the PSPMAA PMs stayed intact in the pH ~7 solution. The PSPMAA diblocks and the PSPMAA triblock stay intact both in the acidic and neutral pH solution. The other PSPMAA PMs released most of the encapsulated fluorescent probe in the more acidic environment. Comparing our results with other studies, our PMs might be suitable for biomedical applications.
| Item Type: | Thesis (Scientific Research Project) |
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| Supervisor name: | Raffa, P. and Picchioni, F. |
| Degree programme: | Science Education and Communication |
| Thesis type: | Scientific Research Project |
| Language: | English |
| Date Deposited: | 17 Apr 2023 09:59 |
| Last Modified: | 17 Apr 2023 09:59 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/29636 |
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