Martens, Ilse (2023) The role of PEX5 in peroxisomal matrix protein import. Bachelor's Thesis, Biology.
|
Text
bBIO_2023_MartensIlse.pdf Download (774kB) | Preview |
|
![[img]](https://fse.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
toestemming.pdf Restricted to Registered users only Download (126kB) |
Abstract
Peroxisomes are semi-autonomous organelles present in all eukaryotes. They are involved in important metabolic pathways. Proteins that are involved in the biogenesis of peroxisomes are called peroxins or PEX proteins. Peroxisomes do not contain their own DNA, so peroxisomal proteins are synthesized elsewhere before being transported to peroxisomes. This thesis will focus on the transport of proteins destined for the peroxisomal matrix, also called peroxisomal matrix protein import. Several diseases can arise when something goes wrong during peroxisomal matrix import so it is important to understand the mechanism. The exact mechanism of peroxisomal matrix protein import has been disputed for several years. Two main models have existed for about 20 years to explain the mechanism of peroxisomal matrix protein import, until a third model came along in 2022. Mainly the role of the peroxin PEX5 is disputed in these models, so the three models are described with a focus on the role of PEX5. It was found that in two models PEX5 enter the matrix of peroxisomes entirely, namely the PEX5 as extended shuttle and PEX5 as cargo accompanier models. In one model PEX5 inserts in the peroxisomal membrane and forms a transient pore, this model is called membrane shuttle model. The models were compared, and it was concluded that PEX5 most likely enters the peroxisomal matrix completely before being pulled out as described by Skowyra and Rapoport (2022).
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Klei, I.J. van der |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 05 Jul 2023 11:20 |
| Last Modified: | 05 Jul 2023 11:20 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/30293 |
Actions (login required)
 |
View Item |