Siampakou, Evangelina (2023) mTOR-Mediated Regulation of Cancer Metabolism. Bachelor's Thesis, Biology.
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Abstract
Altered cellular metabolism is one of the hallmarks of cancer development and progression since rapidly proliferating cells have elevated requirements for energy and biosynthesis. The mechanistic target of rapamycin (mTOR) signalling pathway has attracted attention due to its regulatory influence on metabolism and cell growth. Cancer cells exploit the signalling activity of mTOR to stimulate anabolic processes while inhibiting catabolism in order to create biomass and support uncontrolled growth. The present thesis explores the effects of mTOR-mediated signalling in the metabolism of cancer cells while focusing on the most fundamental processes that include glycolysis, nucleotide, fatty acid and protein synthesis as well as protein degradation and autophagy.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Calkhoven, C.F. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 10 Jul 2023 08:33 |
| Last Modified: | 10 Jul 2023 08:33 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/30388 |
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