Trivanović, Mark (2023) Peripheral Exercise-induced Factors as Boosters of Adult Hippocampal Neurogenesis in Healthy Aging and Alzheimer’s Disease. Bachelor's Thesis, Biology.
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Abstract
Levels of adult hippocampal neurogenesis (AHN) gradually decrease with age. However, Alzheimer’s disease (AD) patients exhibit a significantly sharper drop in AHN levels compared to age-matched controls. Ameliorating AHN malfunction by promoting inherent AHN holds great potential for recovering or delaying learning and memory impairment from the disease. Physical activity, such as exercise, has emerged as a prominent, accessible, and cost-effective booster of AHN. Exercise leads to an upregulation of expression of factors from peripheral tissues, like liver and muscle, which are in turn transported to the brain via blood. Hence, this thesis focuses on the roles of exercise-induced factors in improving hippocampal function by promoting neurogenesis, increasing synaptic plasticity and cerebral blood flow. Particular spotlight is put on identifying the specific molecules involved in exercise-induced AHN amelioration. Administration of these factors to elderly people or AD patients unable to engage in physical activity due to preexisting conditions has the potential to mimic the positive effects of exercise, thus providing a safe alternative.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Zee, E.A. van der and Eisel, U.L.M. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 10 Jul 2023 14:21 |
| Last Modified: | 16 Nov 2023 08:06 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/30493 |
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