Extracellular matrix alterations that might increase the risk for COPD patients to develop lung cancer

Kleissen, Rosalie (2023) Extracellular matrix alterations that might increase the risk for COPD patients to develop lung cancer. Bachelor's Thesis, Biology.

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Abstract

Two pathologies that are known to have a high mortality are Chronic Obstructive Pulmonary Disease (COPD) and lung cancer as they are the fourth cause of death in the world and the first cause of cancer mortality in the world, respectively. Both pathologies share common risk factors, including smoking. It has been shown that patients with COPD have an increased risk to develop lung cancer. Current data show that the extracellular matrix composition and architecture changes with certain disease progressions. These changes might precede modifications in cell behavior and therefore actively contribute to the onset of diseases, as could be the case for COPD and lung cancer. Additionally, ECM alterations observed in COPD might contribute to the onset of cancer. However, the process by which the ECM might be involved remains unclear. Therefore, this thesis will give an overview of what has been found in previous research on ECM alterations in COPD and lung cancer, show which ECM alterations were found in both pathologies and explain how these ECM alterations might contribute to the onset of cancer. The thesis will specifically focus on the core matrisome. Core matrisome alterations that were found in both pathologies are a general increase and similar remodeling processes of collagen and increased osteopontin, fibulin-5, fibronectin, tenascin C and hyaluronan levels. While several of these ECM components were only involved in proceses that occur once the mature and/or (...)

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Brandsma, C.A.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	17 Jul 2023 10:26
Last Modified:	17 Jul 2023 10:26
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/30662

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