Investigating the Role of Interleukin 6 In Liver Fibrosis

Chindong, Winnie Kim (2023) Investigating the Role of Interleukin 6 In Liver Fibrosis. Bachelor's Research Project, Pharmacy.

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Abstract

Liver fibrosis is a complex pathological process characterized by excessive deposition of extracellular matrix proteins, leading to liver dysfunction and potential progression to cirrhosis. At The University of Groningen, the Department of Liver Fibrosis and molecular drug targeting carried out research on IL-10 and its receptors in liver macrophages. The goal of the research was to find out what part of IL10 binds to what part of the Il10 receptor. Knowing this can help in mitigating liver fibrosis. Part of the experiment carried out in this research was to stimulate the macrophages with a few factors such as LPS, IL10, and parts of IL-10 known as P1 and P2 and investigate the amount of cytokines they produce. For this part of the experiment, the pCR was used with a focus on detecting IL-6 DNA. To delve a little deeper, Interleukin-6 (IL-6) is a multifunctional cytokine and has emerged as a key player in the pathogenesis of liver fibrosis. However, the precise mechanisms by which IL-6 influences liver fibrosis remain incompletely understood. The PCR test result showed various amounts of IL-6 when liver macrophages were stimulated. This thesis aims to comprehensively explore the role of IL-6 in liver fibrosis, focusing on its impact on hepatic stellate cells (HSCs), inflammatory responses, and fibrogenesis. Additionally, the potential therapeutic implications of targeting the IL-6 pathway in the management of liver fibrosis will be investigated.

Item Type:	Thesis (Bachelor's Research Project)
Supervisor name:	Poelstra, K.
Degree programme:	Pharmacy
Thesis type:	Bachelor's Research Project
Language:	English
Date Deposited:	02 Aug 2023 12:18
Last Modified:	09 Aug 2023 14:24
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/30670

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