Factors Involved in the Ethiology of Early Onset Preeclampsia and New Possible Treatments

Bosman, Zilla (2023) Factors Involved in the Ethiology of Early Onset Preeclampsia and New Possible Treatments. Bachelor's Thesis, Biology.

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Abstract

Preeclampsia (PE) is a hypertensive disorder during pregnancy, seen after 20 weeks of gestation, which often occurs with proteinuria. Although PE is the second most common complication in pregnancy, with a prevalence of 5-8% in all pregnant women, the ethiology of PE is still unknown. This thesis focusses on new possible therapies that prevent the adverse effects on mother and child seen in PE. The focus is thereby on the factors involved in the ethiology of PE, including immune cells, placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin. Because the ethiology is still unclear, the treatment for PE is limited to early delivery and medication use including aspirin, statins, metformin and esomeprazole. However, these drugs do not inhibit the progression of the disease. Therefore, new effective treatments are needed. The second part of this thesis focusses on the possible therapies, such as toll--like receptors (TLR) antagonists, placenta-derived mesenchymal stem cells (MSCs), PlGF and relaxin to hamper the progression of PE.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Olivier, J.D.A.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	19 Jul 2023 09:02
Last Modified:	19 Jul 2023 09:02
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/30757

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