The role of oxidized phospholipids in atherosclerosis.

Woudstra, Anne (2023) The role of oxidized phospholipids in atherosclerosis. Bachelor's Thesis, Biology.

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Abstract

Atherosclerotic cardiovascular disease (ASCVD) is the most prevalent cause of death in the Western world. The most important risk factor for ASCVD is elevated plasma low-density lipoprotein (LDL)-cholesterol levels. Oxidation of LDL leads to the formation of ox-LDL, which is taken up by the cells of the arterial wall. Elevated plasma levels of oxidized LDL (ox-LDL) are associated with CVD. Ox-LDL contains high levels of oxidized phospholipids (oxPL). OxPL itself is highly pro-inflammatory and pro-atherogenic in mice. In humans, oxPL also circulates on lipoprotein (a) [Lp(a)], which is also hypothesized to be pro-atherogenic. Lp(a) plasma levels are elevated in ~20% of all humans and are associated with increased ASCVD. This has been attributed to the oxPL circulating on Lp(a). This review will focus on the role of oxPL, and thus both ox-LDL and Lp(a), in ASCVD-related morbidity and mortality.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Westerterp, M.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	09 Aug 2023 14:19
Last Modified:	09 Aug 2023 14:19
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/31058

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