Gooijert, Mark (2023) The protective and pathogenic roles of CD36 in multiple sclerosis. Bachelor's Thesis, Biology.
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Abstract
CD36 is a transmembrane protein receptor expressed on various cell types, including immune cells and endothelial cells. It plays a complex role in multiple biological processes, such as lipid metabolism, inflammation, and phagocytosis, and has been implicated in mechanisms in diseases like multiple sclerosis (MS). It is involved in myelin uptake by macrophages and microglia. However, elevated expression in MS has been reported to correlate with both protective and pathogenic effects. This thesis examines this dual role of CD36 in MS based on a review of recent literature. Despite its potential for both protective and pathogenic effects, the prevailing evidence suggests that CD36 primarily exerts a protective influence. CD36 demonstrates anti-inflammatory properties, attenuating neuroinflammation, and promoting myelin debris clearance, thereby fostering central nervous system (CNS) repair and remyelination. CD36's pathogenic implications are acknowledged, however most of these findings are merely correlations and there is no direct connection. Its predominantly beneficial impact highlights its potential as a therapeutic target to mitigate MS progression. This analysis provides insights into the intricate interplay of CD36 in MS, mostly highlighting the protective role CD36 plays in MS, encouraging further research to harness its protective mechanisms for innovative therapeutic strategies.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Bogaart, G. van den |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 23 Aug 2023 14:11 |
| Last Modified: | 23 Aug 2023 14:11 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/31255 |
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