Koll, Lisanne (2023) The dual role of inflammation: acute versus chronic inflammation resulting from genomic instability in cancer. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Genomic instability is one of the most recently introduced hallmarks of cancer and a common feature of almost all human cancers. Genomic instability involves changes in the genome including structural and numerical alterations. Increasing evidence has demonstrated the susceptibility of cancer cells to be recognized by the immune system due to defects in genome maintenance. Both genomic and chromosomal instability can lead to the release of DNA into the cytoplasm, both directly or through the formation and rupture of micronuclei. Cytoplasmic DNA is sensed by cytoplasmic sensors such as cyclic GMP-AMP synthase (cGAS), which results in a type 1 interferon (IFN) response through the activation of stimulator of interferon genes (STING). This type I interferon response induces an acute anti-tumor immune response. However, when acute inflammatory signaling becomes chronic through consistent inflammation, it leads to potential pro-tumorigenic effects, causing aggressive metastatic tumor growth. A gap persists in our current knowledge regarding the molecular differences between acute and chronic inflammation resulting from genomic instability. This essay aims to investigate the intricate association between genomic instability and inflammation, specifically focusing on understanding the mechanisms through which acute inflammation promotes anti-tumor responses, whereas chronic inflammation promotes pro-tumorigenic immune responses.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Vugt, M.A.T.M. van and Bruyn, Dr. Marco de |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 29 Nov 2023 10:32 |
| Last Modified: | 01 Dec 2023 10:05 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/31687 |
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