Impairment of place and grid cells and their effect on cognitive deficits in Alzheimer's Disease

Kuiper, Jente (2023) Impairment of place and grid cells and their effect on cognitive deficits in Alzheimer's Disease. Bachelor's Thesis, Biology.

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disease associated with spatial disorientation and loss of spatial memory. The onset of AD begins decades before the onset of spatial orientation deficits, which is why there is a need for biomarkers that can detect AD in a preclinical stage. The impairment of place and grid cells due to the progression of AD is thought to underly the loss of spatial memory and navigation. To find biomarkers, the deterioration of place and grid cells due to AD progression, needs to be fully understood. In this paper, it becomes clear that the deterioration of place and grid cells starts with the impairment of signal transfer towards grid neurons. A subsequent dysfunction of grid cells leads to impaired signal transfer between place and grid cells. Place cells begin to deteriorate after grid cells begin to lose their function. These network dysfunctions will eventually lead to spatial memory and navigation deficits. It has been suggested that the impaired signal transfer could be used as an early biomarker, along with the impairment of grid cells. In addition can the performance of preclinical AD risk patients in a path integration task be used as an early biomarker.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Zee, E.A. van der
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	30 Nov 2023 09:39
Last Modified:	30 Nov 2023 09:39
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/31688

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