Ruo, Matilde (2023) Exploring the potential benefits of dietary intervention on depression through modulation of the gut microbiota. Bachelor's Thesis, Biology.
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Abstract
The following study aims at analysing dietary intervention as novel treatment approach for depression via modulation of the gut microbiota, since current pharmacological treatments lack efficacy and present various side effects. The current literature already supports the influence of diet on depression as well as the modulatory effects of diet on gut microbiota composition. Hence, dietary supplementations are proposed to exhibit positive effects on the gut microbiota composition resulting in alleviation and/or prevention of depression. The current research first presents strong evidence for a causal correlation between the gut microbiota composition and depression in both human and animal studies. Indeed, dysbiosis is clearly associated with depressive symptoms and induced depression in animal model results in gut microbiota alterations. Secondly, the link between dietary modulation, gut microbiota composition, and incidence of depressive symptoms is illustrated. Specifically, probiotics, prebiotics, and certain foods (walnuts, almonds, and fermented beverage) are demonstrated to yield beneficial effects on gut health population and depression. Conclusively, substantial evidence is presented to infer that dietary interventions seem effective treatments to ameliorate depressive symptoms via the regulation of the gut microbiota. Lastly, the potential mechanisms underlying the pathogenesis of depression involving the gut microbiota are hypothesised.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Drion, C.M. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 21 Dec 2023 09:30 |
| Last Modified: | 21 Dec 2023 09:34 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/31755 |
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