Teertstra, Stefan (2024) INTERLEUKIN-10: EFFECTS ON 264.7 MURINE MACROPHAGES AND POTENTIAL AS NOVEL LIVER FIBROSIS THERAPEUTIC. Bachelor's Research Project, Pharmacy.
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Abstract
Liver fibrosis, the excessive production and accumulation of scar tissue in the liver, is a potentially fatal disease with no current pharmacotherapeutic cure, leaving liver transplantation as the only option. This study aimed to evaluate the potential of interleukin-10 (IL-10), a strong anti-inflammatory cytokine, in treating liver fibrosis by examining its effects on macrophages. Although IL-10 was found to have no significant effect on the expression of the IL-10 receptor α or NO production of the RAW cells, it was found to down-regulate the gene expression of TNF-α, a prominent inflammatory cytokine
| Item Type: | Thesis (Bachelor's Research Project) |
|---|---|
| Supervisor name: | Poelstra, K. |
| Degree programme: | Pharmacy |
| Thesis type: | Bachelor's Research Project |
| Language: | English |
| Date Deposited: | 09 Apr 2024 09:30 |
| Last Modified: | 09 Apr 2024 09:30 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/32254 |
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