Visser, Marije (2024) Interactions between Dietary Niacin and Sucrose Intake on Body Weight and Food Intake in Mice. Research Project 2 (major thesis), Behavioural and Cognitive Neurosciences.
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Abstract
Several sources of data suggest that obesity rates differ between countries that fortify their foods with niacin (also known as vitamin B3) and those that do not, which leads to the question whether niacin is involved with the metabolic disorder. Niacin plays a role in the breakdown of carbohydrates and nowadays people in many countries receive an excessive amount of niacin through their diet. Correlations between niacin intake and obesity rates have already been observed, but no causation has been established yet. In this study, we aimed to determine whether excessive dietary niacin leads to increased weight gain and food intake compared to a diet containing the minimal niacin requirement, when mice are presented with 30% sucrose access. Firstly, the minimal required niacin for mice was established by stepwise lowering niacin supplementation when mice were on a niacin-free diet. From this, we concluded that, under the circumstances of our experiment, mice do not need any niacin in their diet as they are able to convert tryptophan into niacin. For the second part of the experiment, half of a new cohort of mice received a control diet and the other half received a niacin-deficient diet. Half of these mice had access to a 30% sucrose solution. Once every 3 days, body weight, food intake, and, if applicable, sucrose intake were measured. Additionally, at the beginning and the end of the experiment, lean mass and fat mass were measured with echoMRI. Two-way ANOVA and repeated-measures ANOVA revealed no effect of dietary niacin, sucrose or the interaction between the two in females for any of the measured factors. In males, only excessive niacin independently of sucrose intake resulted in a higher body weight. However, the 30% sucrose solution failed to significantly increase body weight in both sexes. Further studies are required to investigate if the observed pattern persists in the presence of a diet that is successful at inducing weight gain.
| Item Type: | Thesis (Research Project 2 (major thesis)) |
|---|---|
| Supervisor name: | Scheurink, A.J.W. |
| Degree programme: | Behavioural and Cognitive Neurosciences |
| Thesis type: | Research Project 2 (major thesis) |
| Language: | English |
| Date Deposited: | 30 Aug 2024 11:59 |
| Last Modified: | 30 Aug 2024 13:08 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/34054 |
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