Where and how does neuroplasticity lead to therapeutic changes?

Palm, Lorenzo (2024) Where and how does neuroplasticity lead to therapeutic changes? Master's Thesis / Essay, Behavioural and Cognitive Neurosciences.

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Abstract

The neuroplasticity theory of depression posits that the brain’s ability to reorganize and form new connections plays a central role in both the development and treatment of depression. Extensive research connects brain atrophy observed in depression with the therapeutic and neuroplastic action of compounds like selective serotonin reuptake inhibitors (SSRIs), ketamine, and classic psychedelics. However, enhanced neuroplasticity can also have detrimental effects, as seen for example in the reward pathways in both addiction and depression. This review thus addresses two important research questions: 1. Where in the brain does neuroplasticity lead to therapeutic changes? 2. How do these plasticity changes translate into cognitive and emotional well-being? We begin the essay by examining recent evidence supporting the role of neuroplasticity in psychedelics and other antidepressant treatments. Then, we explore which brain regions are most involved in depression and might benefit from therapeutic neuroplasticity. Finally, we propose a hypothesis on how neuroplasticity could contribute to improvements in behavior, cognition, and emotion by stimulating psychological flexibility, and how this could be investigated in the future.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Kas, M.J.H. and Boesjes, R.
Degree programme:	Behavioural and Cognitive Neurosciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	16 Oct 2024 07:33
Last Modified:	16 Oct 2024 07:33
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/34321

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